Antiosteoporotic and antioxidant activities of diterpenoids from the Vietnamese soft corals Sinularia maxima and Lobophytum crassum

作者：Nguyen Phuong Thao; Bui Thi Thuy Luyen; Lee Sang Hyun; Jang Hae Dong^*; Phan Van Kiem; Chau Van Minh; Kim Young Ho

来源：Medicinal Chemistry Research, 2015, 24(9): 3551-3560.

DOI：10.1007/s00044-015-1395-8

• Sinularia maxima
• Lobophytum crassum
• Soft coral
• Diterpenoid
• Antiosteoporosis
• Antioxidant

Marine organisms possess bioactive potential with tremendous pharmaceutical promise. The purpose of the present study was to investigate the antioxidant (peroxyl radical-scavenging and reducing capacities) and antiosteoporotic activities of isolated constituents (1-26) from the soft corals Sinularia maxima and Lobophytum crassum on pre-osteoblastic MC3T3-E1 cells and pre-osteoclastic RAW 264.7 cells. Among the isolated compounds, 7, 9, 17, 18, and 20 (10.0 mu M) exhibited significant peroxyl radical-scavenging capacity, with TE values ranging from 4.00 +/- 0.14 to 9.06 +/- 0.33 mu M. In addition, compounds 1, 5, 7, 20, and 24 significantly stimulated the differentiation of pre-osteoblastic MC3T3-E1 cells by increasing collagen synthesis and/or mineralization functions of osteoblasts, while compounds 1, 5-8, 12, 14-22, 24, and 26 showed significant inhibition of TRAP in NF-kappa B ligand-induced osteoclastic RAW 264.7 cells, with values ranging from 99.11 +/- 1.36 to 61.54 +/- 1.61 %. These results indicate that the soft corals S. maxima and L. crassum are excellent sources among the antioxidant and antiosteoporotic marine invertebrates.

• 出版日期2015-9