Anti-GQ1b syndrome. Report of four cases

作者：Uribe S M Reinaldo; Suarez H Felipe; Sandoval R Patricio; Mellado T Patricio

来源：Revista Medica de Chile, 2013, 141(9): 1211-1215.

DOI：10.4067/S0034-98872013000900016

• Encephalitis
• Gangliosides
• Guillain Barre syndrome
• Miller Fisher syndrome
• Ophthalmoplegia

Anti-GQ1b syndrome includes Miller Fisher Syndrome (MFS), Guillain Barre Syndrome (GBS), Bickerstaff%26apos;s brain stem encephalitis (BBE) and Acute Ophtamoplegia (AO). We report four patients aged 16 to 76 years, with anti-GQ1b syndrome. All presented with MFS, one of them evolved to GBS pharyngeal-cervical-brachial variant and other to GBS with BBE. All had a previous history of diarrhea or upper respiratory tract infection. All had positive anti-GQ1b serum antibodies. Both brain magnetic resonance imaging and cerebrospinal fluid analysis were normal. Electrophysiology studies were compatible with a demyelinating disease. Two patients needed airway protection with an orotracheal tube and developed dysautonomia. All four patients were treated with immunomodulation. On the sixth month follow-up, patients had only minimal alterations in the neurological examination.

• 出版日期2013-9