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摘要
The poly(1,4-butylene terephthalate-co-DL-lactide) (BLA) copolymers were successfully prepared by the melt reaction between poly(1,4-butylene terephthalate) (PBT) and DL-oligo(lactic acid) (OLA) in the presence of 1,4-butanediol (BDO) without any catalysts. The transesterification between butylenes terephthalate (BT), 1,4-butanediol and lactide (LA) segments during the reaction was confirmed by the H-1 NMR analysis. The chemical structure of the copolymers was further investigated by the C-13 NMR and two-dimensional H-1-C-13 HMQC (heteronuclear multiple quantum correlation) technique. The effect of reaction temperatures and the starting feed ratios on the molecular microstructures, molecular weights, solubility and thermal stability of the copolyesters was extensively studied. The sequence length of BT (N-BT) was found to play a vital role on the solubility and thermal behaviors of the resulting copolyesters. The copolyesters with N-BT in the range of 2.8 and 7.3 were soluble in chloroform. The B(10)LA(40) copolyester with the shortest N-BT of 2.8 exhibited almost the lowest glass-transition temperature (T-g), crystallization temperature (T-c), melting temperature (T-m), crystallization enthalpy (Delta H-c) and melting enthalpy (Delta H-m) as compared with the other copolyesters. The copolyester of B(10)LA(40) was able to hydrolytically degrade and the fabricated scaffold that showed good biocompatibility towards the human bone marrow stromal cells.
- 出版日期2010-1
- 单位南昌大学
