Arterial Blood Pressure and Long-Term Exposure to Traffic-Related Air Pollution: An Analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE)

作者：Fuks Kateryna B^*; Weinmayr Gudrun; Foraster Maria; Dratva Julia; Hampel Regina; Houthuijs Danny; Oftedal Bente; Oudin Anna; Panasevich Sviatlana; Penell Johanna; Sommar Johan N; Sorensen Mette; Tiittanen Pekka; Wolf Kathrin; Xun Wei W; Aguilera Inmaculada; Basagana Xavier; Beelen Rob; Bots Michiel L; Brunekreef Bert; Bueno de Mesquita H Bas; Caracciolo Barbara; Cirach Marta; de Faire Ulf; de Nazelle Audrey; Eeftens Marloes; Elosua Roberto; Erbel Raimund

来源：Environmental Health Perspectives, 2014, 122(9): 896-905.

DOI：10.1289/ehp.1307725

BACKGROUND: Long-term exposure to air pollution has been hypothesized to elevate arterial blood pressure (BP). The existing evidence is scarce and country specific. %26lt;br%26gt;OBJECTIVES: We investigated the cross-sectional association of long-term traffic-related air pollution with BP and prevalent hyper-tension in European populations. %26lt;br%26gt;METHODS: We analyzed 15 population-based cohorts, participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE). We modeled residential exposure to particulate matter and nitrogen oxides with land use regression using a uniform protocol. We assessed traffic exposure with traffic indicator variables. We analyzed systolic and diastolic BP in participants medicated and nonmedicated with BP-lowering medication (BPLM) separately, adjusting for personal and area-level risk factors and environmental noise. Prevalent hyper-tension was defined as %26gt;= 140 mmHg systolic BP, or %26gt;= 90 mmHg diastolic BP, or intake of BPLM. We combined cohort-specific results using random-effects meta-analysis. %26lt;br%26gt;RESULTS: In the main meta-analysis of 113,926 participants, traffic load on major roads within 100 m of the residence was associated with increased systolic and diastolic BP in nonmedicated participants [0.35 mmHg (95% CI: 0.02, 0.68) and 0.22 mmHg (95% CI: 0.04, 0.40) per 4,000,000 vehicles x m/day, respectively]. The estimated odds ratio (OR) for prevalent hyper-tension was 1.05 (95% CI: 0.99, 1.11) per 4,000,000 vehicles x m/day. Modeled air pollutants and BP were not clearly associated. %26lt;br%26gt;CONCLUSIONS: In this first comprehensive meta-analysis of European population-based cohorts, we observed a weak positive association of high residential traffic exposure with BP in nonmedicated participants, and an elevated OR for prevalent hyper-tension. The relationship of modeled air pollutants with BP was inconsistent.

• 出版日期2014-9