A mechanism for selective lymphocyte homing in bovine hemal nodes

作者：Zhang Weidong; Nasu Tetsuo; Yasuda Masahiro^*

来源：Veterinary Immunology and Immunopathology, 2013, 156(3-4): 211-214.

DOI：10.1016/j.vetimm.2013.10.007

• Bovine
• Flow cytometry
• Hemal node
• Immunohistochemistry
• MECA-79

The distribution and abundance of MECA-79(+) cells in bovine hemal nodes (HNs) was analyzed. In addition, T cell subsets which expressed the homing receptor L-selectin were analyzed by flow cytometry. The frequency of MECA-79(+) HNs varied depending on the location. There were 61, 33, and 17% MECA-79(+) HN in the subcutaneous region, along the abdominal aorta and in the mesenteric region, respectively. MECA-79(+) cells in mesenteric lymph nodes were mainly distributed in the paracortex. Many MECA-79(+) cells were distributed in the perifollicular area of HNs and a few positive cells were also located in the paracortical and interfollicular areas. CD4(+) and CD8(+) L-selectin(+) cells were significantly higher in MECA-79(+) HNs compared to MECA-79(-) HNs. The data suggest that a selective lymphocyte homing mechanism exists in bovine HNs, which could be related to functional differences between locations.

• 出版日期2013-12-15