Associations Between Plasma Polyunsaturated Fatty Acids, Plasma Stearoyl-CoA Desaturase Indices and Body

作者：Vinknes Kathrine J^*; Elshorbagy Amany K; Drevon Christian A; Nurk Eha; Tell Grethe S; Nygard Ottar; Vollset Stein E; Refsum Helga

来源：Obesity, 2013, 21(9): E512-E519.

DOI：10.1002/oby.20457

Objective: Stearoyl-CoA desaturase (SCD)-1 deficient mice are resistant to obesity and plasma SCD indices are related to obesity in humans. Both n-3 and n-6 polyunsaturated fatty acids (PUFA) regulate expression of the SCD enzymes. Whether higher plasma PUFA were associated with lower SCD indices in humans was examined. %26lt;br%26gt;Design and Methods: Population-based study of 2,021 elderly subjects from the Hordaland Health Study. Using multivariate linear regression, the cross-sectional associations among plasma PUFA, estimated SCD indices (from fatty acid profiles in plasma total lipids), and fat mass measured by dual-energy X-ray absorptiometry were explored. Two plasma SCD indices were used: SCD-16 (16: 1n-7/16: 0) and SCD-18 (18: 1n-9/18: 0). %26lt;br%26gt;Results: Plasma total, n-6 and n-3 PUFA were inversely associated with both SCD indices (P%26lt;0.001 for all). Among the individual PUFA, 18: 2n-6 showed the strongest association with SCD-16 (partial r= 20.59, P%26lt; 0.001) followed by 20: 5n-3 (partial r=0.13; P%26lt; 0.001). Plasma total, n-6 and n-3 PUFA were inversely associated with body fat (P%26lt; 0.001 for all); the associations were markedly attenuated following adjustment for SCD-16. %26lt;br%26gt;Conclusions: The epidemiological data are in line with animal studies and suggest that PUFA may decrease SCD1 activity in humans, with possible reduction in body fat.

• 出版日期2013-9
• 单位河北医科大学