An HIV-infected Pregnant Woman Treated with the Long-term Administration of Antiretroviral Therapy Including Raltegravir

作者：Yaita Kenichiro^*; Inoue Shigeru; Horinouchi Takashi; Kinoshita Masahiro; Unno Mitsuaki; Iwata Osuke; Tanaka Yuhei; Gotoh Kenji; Ishibashi Mikio; Sakai Yoshiro; Masunaga Kenji; Watanabe Hiroshi; Tominaga Masaki

来源：Internal Medicine, 2016, 55(18): 2727-2730.

DOI：10.2169/internalmedicine.55.6653

• raltegravir
• integrase strand transfer inhibitor
• plasma concentration
• HIV
• pregnancy

A 27-year-old HIV-infected pregnant Japanese woman was admitted to our hospital at gestational week 14. The patient's HIV viral load was 71,000 copies/mL, and her CD4 cell count was 147 cells/mm(3). Zidovudine, lamivudine, and lopinavir/ritonavir were administered at gestational week 18. Because the viral load increased to 222,000 copies/mL at the initiation of antiretroviral therapy, we added raltegravir. The decrease in the viral load was satisfactory, and a caesarean delivery was performed. Although the plasma concentration of raltegravir in the neonate was significantly high (2,482 ng/mL), no adverse event was confirmed. There was no evidence of the mother-to-child transmission of HIV.

• 出版日期2016