Multiple inductive effects of carbamazepine on combined therapy with paliperidone and amlodipine

作者：Akamine Y; Uehara H; Miura M^*; Yasui Furukori N; Uno T

来源：Journal of Clinical Pharmacy and Therapeutics, 2015, 40(4): 480-482.

DOI：10.1111/jcpt.12286

• carbamazepine
• CYP3A
• P-glycoprotein
• pharmacodynamics
• pharmacokinetics

What is known and objectiveCarbamazepine is a potent inducer of cytochrome P450 3A and P-glycoprotein. However, there are no reports of the effects of carbamazepine on more than one co-administered drug.
Case summaryA 53-year-old female patient with schizophrenia and hypertension was on paliperidone 12mg/day and amlodipine 5mg/day. When carbamazepine was added to this prescription, the plasma concentrations of both drugs decreased dramatically in a dose-dependent manner. Although the patient's psychotic symptoms did not change, as a result, her mean blood pressure increased to 1601/1036mmHg from 1384/914mmHg at a carbamazepine dose of 600mg/day.
What is new and conclusionTheses cases show the effect of carbamazepine induction on two drugs simultaneously. Care is required when carbamazepine is added to drug regimens including paliperidone or amlodipine alone or together.

• 出版日期2015-8