科研之友
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摘要
Gender differences may affect human immunodeficiency virus (HIV) infection in humans and may be related to fluctuations in sex hormone concentration. The different percentage of male and female cats observed to be infected by feline leukemia virus (FeLV) or feline immunodeficiency virus (FIV) has been traditionally explained through the transmission mechanisms of both viruses. However, sexual hormones may also play a role in this different distribution. To study this possibility, 17 beta-estradiol, progesterone, testosterone, and dehydroepiandrosterone (DHEA) concentrations were analyzed using a competitive enzyme immunoassay in the plasma of 258 cats naturally infected by FIV (FIV+), FeLV (FeLV+), or FeLV and FIV (F-F+) or negative for both viruses, including both sick and clinically healthy animals. Results indicated that the concentrations of 17 beta-estradiol. and testosterone were significantly higher in animals infected with FIV or FeLV (P %26lt; 0.05) than in negative cats. Plasma concentrations of DHEA in cats infected by either retrovirus were lower than in negative animals (P %26lt; 0.05), and F-F+ cats had significantly lower plasma values than monoinfected cats (P %26lt; 0.05). No significant differences were detected in the plasma concentration of progesterone of the four groups. No relevant differences were detected in the hormone concentrations between animal genders, except that FIV+ females had higher DHEA concentrations than the corresponding males (P %26lt; 0.05). In addition, no differences were observed in the hormone concentrations between retrovirus-infected and noninfected animals with and without clinical signs. These results suggest that FIV and FeLV infections are associated with an important deregulation of steroids, possibly from early in the infection process, which might have decisive consequences for disease progression.
- 出版日期2012-2
