An efficient one pot three component synthesis of fused pyridines via electrochemical approach

作者：Upadhyay Abhishek; Sharma Laxmi Kant; Singh Vinay K; Singh Rana Krishna Pal^*

来源：Tetrahedron Letters, 2016, 57(50): 5599-5604.

DOI：10.1016/j.tetlet.2016.10.111

• Multicomponent reaction
• Electrosynthesis
• Atom economy
• 6-Amino uracil
• Dimedone
• Malononitrile

A convenient and economical method is developed for the synthesis of pyrido[2,3-d]pyrimidine derivatives by electrochemically induced condensation of various aromatic aldehydes, dimedone or malononitrile and 6-amino uracil. The reaction is carried out in an undivided cell, at a constant current in the presence of NaBr as supporting electrolyte and ethanol as solvent.

• 出版日期2016-12-14