Hemoglobin Constant Spring is markedly high in women of an ethnic minority group in Vietnam: A community-based survey and hematologic features

作者：Van Hoa Nguyen; Sanchaisuriya Kanokwan^*; Wongprachum Kasama; Mau Duyen Nguyen; Thi Thuy Hoa Phan; Van Thang Vo; Sanchaisuriya Pattara; Fucharoen Supan; Schelp Frank P

来源：Blood Cells, Molecules, and Diseases, 2014, 52(4): 161-165.

DOI：10.1016/j.bcmd.2013.12.002

• Hemoglobin Constant Spring
• Thalassemia
• Hemoglobinopathies
• Ethnic minority
• Vietnam

A community-based survey was conducted to determine the prevalence and gene frequency of Hemoglobin Constant Spring (Hb CS) and other forms of thalassemia among an ethnic minority in Vietnam. A total of 298 ethnic minority women, the CO-Tu, participated. Hematological parameters and hemoglobin profiles were analyzed using standard automated analyzers. Alpha-and beta-thalassemia mutations were identified using polymerase chain reaction (PCR) based technology. Of the 298 women, 141 (473%) carried thalassemia genes. Hemoglobin Constant Spring (Hb CS) is the most common with a markedly high frequency of 0.143 (overall prevalence = 26.2%). The heterozygous state of Hb CS was found in one-fifth (20.5%) of women participating. Seven women (2.4%) were Hb CS homozygote. The overall prevalence for Hb E was 13.8%, and 10.7% for alpha(+)-thalassemia. Other forms of thalassemia included 0.67% beta-thalassemia, and 0.34% Hb Pakse. None of the participants had the alpha(0)-thalassemia gene. The study provides basic epidemiological information about Hb CS as well as other forms of thalassemia for a specific group of an ethnic minority in Vietnam. The data will be useful for further study on the distribution of thalassemia in Southeast Asia. 2013 Elsevier Inc.

• 出版日期2014-4