Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress

作者：Sloop Joseph C

来源：Journal of Chemistry, 2017, 2017: 2860123.

DOI：10.1155/2017/2860123

<jats:p>Heterocyclic molecules incorporating fluorinated isoquinoline components are found in many medicinally and agriculturally important bioactive products as well as industrially impactful materials. Within the past decade, a variety of isoquinolinic ring assembly techniques has enabled the introduction of diverse fluorine-containing functionalities which can enhance potential bioactivity and industrial utility. This review examines recent noncatalyzed and transition metal catalyzed synthetic approaches to the assembly of isoquinoline derivatives that are ring-fluorinated and/or result in the incorporation of fluorine-containing functional groups. Specifically, efficient synthetic methods and regioselectivity in the incorporation of functional groups into isoquinoline ring systems are examined.</jats:p>

• 出版日期2017
• 单位Georgia Gwinnett College