Functional foldamers that target bacterial membranes: The effect of charge, amphiphilicity and conformation

作者：Patil Sen Yogita; Dennison Sarah R; Snape Timothy J^*

来源：Bioorganic & Medicinal Chemistry, 2016, 24(18): 4241-4245.

DOI：10.1016/j.bmc.2016.07.017

• Foldamer
• Antibacterial
• Membrane
• Diarylureas
• Conformation

By varying the molecular charge, shape and amphiphilicity of a series of conformationally distinct diary-lureas it is possible to control the levels of phospholipid membrane lysis using membranes composed of bacterial lipid extracts. From the data obtained, it appears as though the lysis activity observed is not due to charge, conformation or amphiphilicity in isolation, but that surface aggregation, H-bonding and other factors may also play a part. The work provides evidence that this class of foldamer possesses potential for optimisation into new antibacterial agents.

• 出版日期2016-9-15