科研之友
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摘要
A novel protocol for the semi-synthesis of docetaxel was achieved in four steps from 10-deacetyl baccatin III with an overall yield of 50%. The key step is the selective protection of the C(7) and C(10) hydroxyl groups of 10-deacetyl baccatin III, utilizing benzyl chloromate as a selective protecting reagent, which are capable of being conveniently removed by Pd/C under hydrogen atmosphere.
- 出版日期2010-9
- 单位重庆医科大学
