Decreased p21 Expression in HPV-18 Positive Cervical Carcinomas

作者：Huang Lee Wen^*; Seow Kok Min; Lee Chin Cheng; Lin Yu Hung; Pan Hun Shan; Chen Heng Ju

来源：Pathology and Oncology Research, 2010, 16(1): 81-86.

DOI：10.1007/s12253-009-9191-8

• Human papillomavirus (HPV)
• p21
• p53
• p27
• Cervical carcinoma

The aim of this study was to investigate the relationship between different human papillomaviruse (HPV) genotypes and the expression of p53, p21 and p27 in cervical carcinomas. A total of 103 cases of cervical carcinomas were assayed for expression of p53, p21 and p27 by immunohistochemistry. HPV typing was carried out by two polymerase chain reaction-based methods. Overall, HPV prevalence was 97.1% among the cervical carcinomas in this study. HPV-16 was detected in 66% of the tumors, HPV-18 in 7.8%, HPV-16/18 in 7.8% and other HPV types in 15.5%. The expression of p53 and p27 was not related to HPV genotype. However, in the HPV-18 positive cervical carcinomas, expression of p21 was significantly decreased or completely absent (P=0.019). Our results indicated that down-regulation of p21 was strongly associated with HPV-18 positive cervical carcinomas. The significantly lower expression of p21 protein in HPV-18 positive samples compared to HPV-18 negative cervical carcinomas supports the hypothesis that inactivation and degradation of p21 proteins by HPV-18 E7 may play an important role in the carcinogenesis of HPV-18 positive cervical neoplasia.

• 出版日期2010-3