A new drug-loading technique with high efficaciency and sustained-releasing ability via the Pickering emulsion interfacial assembly of temperature/pH-sensitive nanogels

作者：Zhou Guofeng; Zhao Yanbing^*; Hu Jindong; Shen Liang; Liu Wei; Yang Xiangliang

来源：Reactive and Functional Polymers, 2013, 73(11): 1537-1543.

DOI：10.1016/j.reactfunctpolym.2013.08.004

• Pickering emulsion
• Temperature/pH-sensitive
• Nanogel
• Drug loading
• Sustained release

pNIPAM nanogels, which exhibited rich sol-gel transition behavior, have been used extensively in the biomedical fields such as drug delivery, blood vessel embolization and tissue-engineering Owing to their limitation of 3D networks, pNIPAM nanogels have low drug-loading amount and poor sustained releasing properties. In the present research, Pickering emulsion combined with solvent evaporation (PESE) is developed firstly as a new drug-loading technique of pNIPAM nanogels in our knowledge. The entrapment efficiency (EE%) reached nearly 100%, and DOX loading amount (DL%) could reach 15%. Owing to ionic bonding interaction of DOX molecules and sulfonamide groups, DOX loaded PNS nanogels by PESE (PNS-D nanogels) show a slow releasing behavior, only 13.2% for 48 h in pure water, without any burst release. As the ionic strength of media increased, the DOX-releasing amount from PNS-D-10 nanogels increased to 29.5%, 41.6% and 48.0% respectively in 0.9 wt%, 3.0 wt% and 5.0 wt% of NaCl solutions for 48 h. The loading DOX has significant effect on the rheologic behavior of nanogel dispersions. PESE technique is hopeful to be developed as a universal hydrophobic drug loading method of nanogels, and will be extensively applied in drug delivery and tissue engineering.

• 出版日期2013-11
• 单位华中科技大学