Asymptomatic HyperCkemia - What Next?

作者：Loescher W^*

来源：Klinische Neurophysiologie, 2011, 42(4): 226-230.

DOI：10.1055/s-0031-1291230

• creatine kinase
• myopathy
• reference value
• muscle
• biopsy

In the presence of raised serum CK levels the suspicion of subclinical myopathy is frequently raised in asymptomatic patients. However, recent epidemiological studies indicate that the current CK reference values used might be too low and new reference values have been proposed. Before intensive investigations of patients with asymptomatic hyperCKemia are initiated, non-neuromuscular causes, e. g., exercise and drugs, should be excluded. A definitive diagnosis can be reached in approximately 25% of patients if muscle biopsies, biochemical and genetic studies are performed. Overall, the prognosis of asymptomatic hyperCKemia is benign and only a few patients develop a neuromuscular disorder. However, DNA analysis should be undertaken in young women with hyperCKemia because of the possibility of a Duchenne/Becker mutation carrier status. The recently published EFNS guidelines on the diagnostic approach to asymptomatic hyperCKemia are discussed.

• 出版日期2011-12