Dynamic modeling of cellular response to DNA damage based on p53 stress response networks

作者：Qi, Jinpeng^*; Ding, Yongsheng; Shao, Shihuang

来源：Progress in Natural Science:Materials International , 2009, 19(10): 1349-1356.

DOI：10.1016/j.pnsc.2009.03.008

• p53
• DNA damage
• IR
• Cellular networks
• Modelin

Under acute perturbations from the outside, cells can trigger self-defensive mechanisms to fight against genome stress. To investigate the cellular response to continuous ion radiation (IR), a dynamic model for p53 stress response networks at the cellular level is proposed. The model can successfully be used to simulate the dynamic processes of double-strand breaks (DSBs) generation and their repair, switch-like ataxia telangiectasia mutated (ATM) activation, oscillations occurring in the p53-MDM2 feedback loop, as well as toxins elimination triggered by p53 stress response networks. Especially, the model can predict the plausible outcomes of cellular response under different IR dose regimes.

• 出版日期2009-10-10
• 单位东华大学