Association Between Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Maintenance Hemodialysis Patients - Comparison With B-Type Natriuretic Peptide and Cardiac Troponin T

作者：Negishi Kazuaki^*; Kobayashi Mitsuru; Ochiai Izuru; Yamazaki Yuji; Hasegawa Hisashi; Yamashita Takeyoshi; Shimizu Takehisa; Kasama Shu; Kurabayashi Masahiko

来源：Circulation Journal, 2010, 74(12): 2734-2740.

DOI：10.1253/circj.CJ-10-0355

• Biomarker
• Echocardiography
• Fibroblast growth factor-23
• Hemodialysis
• Left ventricular hypertrophy

Background: Fibroblast growth factor 23 (FGF-23) is a novel bone-derived phosphate-regulating hormone, and serum FGF-23 levels are associated with mortality among hemodialysis (HD) patients. However, the pathophysilogical role of FGF-23 in those patients remains unclear, so the association between serum FGF-23 levels and known cardiac biomarkers or echocardiographic measurements were investigated in long-term HD patients without cardiac symptoms.
Methods and Results: The 87 consecutive patients treated in a single HD center (51 males, 36 females, mean age 64 years, mean HD duration 5 8 years) were included in this study. Comprehensive echocardiography was performed after HD Blood samples were obtained before HD Serum FGF-23 levels in dialysis patients were 1,171 +/- 553 pg/ml In univariate analysis, serum phosphate (r=0.443, P<0.001) and calcium levels (r=0.256, P=0.04), left ventricular mass index (LVMI) (r=0.268, P=0.039) were significantly associated with FGF-23 levels. Neither the B-type natriuretic peptide (BNP) nor the cardiac troponin T level was correlated with FGF-23. In multi-variate regression analysis, only LVMI (beta=0.287, P=0.031, confidence interval (CI) 0.390-8.040) and phosphate levels (beta=0.419, P=0.001, CI 57.12-207.7) and calcium levels (beta=0.277, P=0.025, CI 24.95-360.1) remained significantly correlated with FGF-23.
Conclusions: Beside BNP, FGF-23 was identified as a factor that is significantly associated with LVMI FGF-23 could be a novel biomarker of left ventricular overload, which is closely associated with the increased risk of death in HD patients. (Circ J 2010,74 2734-2740)

• 出版日期2010-12