Neuroprotective effect of Fn14 deficiency is associated with induction of the granulocyte-colony stimulating factor (G-CSF) pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibody

作者：Frauenknecht Katrin^*; Bargiotas Panagiotis; Bauer Henrike; von Landenberg Philipp; Schwaninger Markus; Sommer Clemens

来源：Journal of Neuroimmunology, 2010, 227(1-2): 1-9.

DOI：10.1016/j.jneuroim.2010.05.043

• Antiphospholipid antibodies
• Antiphospholipid syndrome
• Fn14
• Granulocyte-colony stimulating factor
• Neuroprotection
• Stroke

Using a transgenic mouse model of ischemic stroke we checked for a possible interaction of antiphospholipid antibodies (aPL) which often cause thromboses as well as central nervous system (CNS) involvement under non-thrombotic conditions and the TWEAK/Fn14 pathway known to be adversely involved in inflammatory and ischemic brain disease. After 7 days, infarct volumes were reduced in Fn14 deficient mice and were further decreased by aPL treatment. This was associated with strongest increase of the endogenous neuroprotective G-CSF/G-CSF receptor system.

• 出版日期2010-10-8