A Copper-Catalyzed Aerobic Cascade Dehydrogenative Dehalogenative Reaction

作者:Liang, Lei; Yang, Guanyu; Wang, Wei; Xu, Fengrong; Niu, Yan; Sun, Qi; Xu, Ping*
来源:Advanced Synthesis & Catalysis, 2013, 355(7): 1284-1290.
DOI:10.1002/adsc.201300026

摘要

A copper-catalyzed cascade dehydrogenative and dehalogenative reaction of halogenated 6-phenyl-4,5-dihydropyridazin-3(2H)-ones to 6-phenylpyridazin-3(2H)-ones has been developed. Moreover, the catalytic system consisting of copper(II) acetate/sodium carbonate/pyridine exhibits high reactivity and selectivity with oxygen as the terminal oxidant.

  • 出版日期2013-5
  • 单位北京大学; 天然药物与仿生药物国家重点实验室