Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats

作者：Xing Ronge^*; He Xiaofei; Liu Song; Yu Huahua; Qin Yukun; Chen Xiaolin; Li Kecheng; Li Rongfeng; Li Pengcheng

来源：Marine Drugs, 2015, 13(5): 3072-3090.

DOI：10.3390/md13053072

• differently regioselective chitosan sulfates
• hypoglycemic activity
• glucose tolerance
• plasma insulin
• alloxan-induced diabetic rats

The present study investigated and compared the hypoglycemic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats. Compared with the normal control rats, significantly higher blood glucose levels were observed in the alloxan-induced diabetic rats. The differently regioselective chitosan sulfates exhibited hypoglycemic activities at different doses and intervals, especially 3-O-sulfochitosan (3-S). The major results are as follows. First, 3,6-di-O-sulfochitosan and 3-O-sulfochitosan exhibited more significant hypoglycemic activities than 2-N-3, 6-di-O-sulfochitosan and 6-O-sulfochitosan. Moreover, 3-S-treated rats showed a more significant reduction of blood glucose levels than those treated by 3,6-di-O-sulfochitosan. These results indicated that -OSO3- at the C3-position of chitosan is a key active site. Second, 3-S significantly reduced the blood glucose levels and regulated the glucose tolerance effect in the experimental rats. Third, treatment with 3-S significantly increased the plasma insulin levels in the experimental diabetic rats. A noticeable hypoglycemic activity of 3-S in the alloxan-induced diabetic rats was shown. Clinical trials are required in the future to confirm the utility of 3-S.

• 出版日期2015-5
• 单位中国科学院海洋研究所; 中国科学院大学