Neolignans and serratane triterpenoids with inhibitory effects on xanthine oxidase from Palhinhaea cernua

作者:Li, Jing; Xu, Ping-Sheng; Tan, Lei-Hong; Zou, Zhen-Xing; Wang, Yi-Kun; Long, Hong-Ping; Zhou, Gan; Li, Guang; Xu, Kang-Ping*; Tan, Gui-Shan*
来源:Fitoterapia, 2017, 119: 45-50.
DOI:10.1016/j.fitote.2017.04.005

摘要

Three new neolignans, lycocernuasides B-D (1-3), three new serratane triterpenoids, lycemuic ketones D (8) and E (9), and lycernuic A (10), together with six known compounds, were isolated from the 75% aqueous EtOH extract of Palhinhaea cernua. Their structures and absolute configurations were established primarily by NMR, HRESIMS and circular dichroism (CD). All compounds were evaluated the inhibitory activities of xanthine oxidase. Compounds 1-3 displayed moderate inhibitory effects on xanthine oxidase with IC50 values of 30.36 mu M, 42.65 mu M and 35.33 mu M, respectively.