A Potential Inhibitor of Rat Aortic Vascular Smooth Muscle Cell Proliferation from the Pollen of Typha angustata

作者：Nguyen Xuan Nhiem; Phan Van Kiem; Chau Van Minh; Lee Jung Jin; Ku Ja Hyeong; Myung Chang Seon; Kim Young Ho^*

来源：Archives of Pharmacal Research, 2010, 33(12): 1937-1942.

DOI：10.1007/s12272-010-1208-z

• Typha angustata
• Typhaceae
• Smooth muscle cell
• Atherosclerosis

By various chromatographic methods, three flavonoids, (2S)-naringenin (1), isorhamnetin 3-O-(2-O-alpha-L-rhamnopyranosyl) beta-D-glucopyranoside (2), typhaneoside (3), and two sterol glycosides, beta-sitosterol-3-O-(6-octadecanoyl) beta-D-glucopyranoside (4) and beta-sitosterol-3-O-(6-octadeca-9Z,12Z-dienoyl) beta-D-glucopyranoside (5), were isolated from the pollen of Typha angustata. Their structures were determined on the basis of spectroscopic analyses. The flavonoids (1 - 3) were evaluated for their effects on the viability and proliferation of rat aortic smooth muscle cells. (2S)-naringenin (1) significantly inhibited cell proliferation in a dose-dependent manner without cytotoxic at concentrations of 30, and 50 mu M; it reduced the number of cells following PDGF-BB treatment to 1.83 +/- 0.30 x 10(4) and 2.20 +/- 0.60 x 10(4) cells/well, respectively. These findings suggest that (2S)-naringenin has antiproliferative effects on aortic smooth muscle cells.

• 出版日期2010-12