Maternal and Neonatal Levels of Perfluoroalkyl Substances in Relation to Gestational Weight Gain

作者：Ashley Martin Jillian; Dodds Linda^*; Arbuckle Tye E; Morisset Anne Sophie; Fisher Mandy; Bouchard Maryse F; Shapiro Gabriel D; Ettinger Adrienne S; Monnier Patricia; Dallaire Renee; Taback Shayne; Fraser William

来源：International Journal of Environmental Research and Public Health, 2016, 13(1): 146.

DOI：10.3390/ijerph13010146

• perfluoroalkyl substances
• gestational weight gain
• environmental contaminants
• birth cohort

Perfluoroalkyl substances (PFASs) are ubiquitous, persistent pollutants widely used in the production of common household and consumer goods. There is a limited body of literature suggesting that these chemicals may alter metabolic pathways and growth trajectories. The relationship between prenatal exposures to these chemicals and gestational weight gain (GWG) has received limited attention. One objective was to analyze the associations among maternal plasma levels of three common perfluoroalkyl substances (perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfanoate (PFHxS)) and GWG. Additionally, we explored whether GWG was associated with cord blood PFAS levels. This study utilized data collected in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada cohort study of 2001 pregnant women. Our analysis quantified associations between (1) maternal PFAS concentrations and GWG and (2) GWG and cord blood PFAS concentrations. Maternal PFOS concentrations were positively associated with GWG (beta = 0.39 95% CI: 0.02, 0.75). Interquartile increases in GWG were significantly associated with elevated cord blood PFOA (OR = 1.33; 95% CI: 1.13 to 1.56) and PFOS (OR = 1.20; 95% CI: 1.03 to 1.40) concentrations. No statistically significant associations were observed between GWG and either measure of PFHxS. These findings warrant elucidation of the potential underlying mechanisms.

• 出版日期2016-1