Toll-deficient Drosophila are resistant to infection by Pneumocystis spp. Additional evidence of specificity to mammalian hosts

作者：Evans Scott E; Leventakos Konstantinos; Ben Ami Ronen; You Dahui; Thakkar Sachin G; Lewis Russell E; Kontoyiannis Dimitrios P^*

来源：Virulence, 2010, 1(6): 523-525.

DOI：10.4161/viru.1.6.13903

• Pneumocystis spp.
• fungal pathogen
• mini host model
• Drosophila melanogaster

Pneumocystis spp. are significant pathogens in a variety of mammals. We tried to establish a Drosophila model of pneumocystosis using either P. murina or P. carinii. Whereas the pathogens were competent in susceptible mice, no infection could be established even in corticosteroid-treated Toll-deficient flies. This further substantiates the tropism described for mammalian hosts.

• 出版日期2010-12