Association between Lifestyle Factors and Quality-Adjusted Life Years in the EPIC-NL Cohort

作者：Fransen Heidi P; May Anne M^*; Beulens Joline W J; Struijk Ellen A; de Wit G Ardine; Boer Jolanda M A; Onland Moret N Charlotte; Hoekstra Jeljer; van der Schouw Yvonne T; Bueno de Mesquita H Bas; Peeters Petra H M

来源：PLos One, 2014, 9(11): e111480.

DOI：10.1371/journal.pone.0111480

The aim of our study was to relate four modifiable lifestyle factors (smoking status, body mass index, physical activity and diet) to health expectancy, using quality-adjusted life years (QALYs) in a prospective cohort study. Data of the prospective EPIC-NL study were used, including 33,066 healthy men and women aged 20-70 years at baseline (1993-7), followed until 31-12-2007 for occurrence of disease and death. Smoking status, body mass index, physical activity and adherence to a Mediterranean-style diet (excluding alcohol) were investigated separately and combined into a healthy lifestyle score, ranging from 0 to 4. QALYs were used as summary measure of healthy life expectancy, combining a person's life expectancy with a weight for quality of life when having a chronic disease. For lifestyle factors analyzed separately the number of years living longer in good health varied from 0.12 year to 0.84 year, after adjusting for covariates. A combination of the four lifestyle factors was positively associated with higher QALYs (P-trend <0.0001). A healthy lifestyle score of 4 compared to a score of 0 was associated with almost a 2 years longer life in good health (1.75 QALYs [95% CI 1.37, 2.14]).

• 出版日期2014-11-4