A Family-Based Association Study Does Not Support DYX1C1 as a Candidate Gene in Dyslexia in Japan

作者：Sugita Katsuo; Uesaka Tomoko; Nomura Jun; Sugita Kiyoko; Inagaki Masumi

来源：International Medical Journal, 2011, 18(2): 130-132.

• developmental dyslexia
• DYX1C1 gene
• PCR mismatch assay

Objective: The aim of the present study was to investigate the role of DYX1C1 gene mutations as a candidate gene for developmental dyslexia (DD) in Japanese children.
Cases and Methods: 15 Cases of DD, 22 non-DD family members of the dyslexia cases, and 60 normal volunteers, participated in this study. We performed screening tests for DYX 1C1 genes (exon 2; -3G > A, exon 10; 1249G > T) by PCR mismatch assay. In addition to these 2 single nucleotide polymorphism (SNP) screened, we examined another SNP of exon 10; 1259C > G, by DNA sequences and analyzed the association between these 3 SNPs and DD.
Results: This study did not support the involvement of DYX1C1 gene variants in this sample of DD and their family members.
Conclusion: We were unable to replicate the supportive findings between the DYX1C1 gene and DD in Japan, perhaps due to genetic and phenotypic heterogeneity.

• 出版日期2011-6