科研之友
微信
新浪微博
Facebook
分享链接
摘要
Pharmacokinetics of mequindox and one of its major metabolites (M) was determined in chickens after intravenous (i.v.), intramuscular (i.m.) and oral administration of mequindox at a single dose of 10 (i.v. and i.m.) or 20 mg/kg b.w. (oral). Plasma concentration profiles were analyzed by a non-compartmental pharmacokinetic method. Following i.v., i.m. and oral administration, the areas under the plasma concentration-time curve (AUC(0-infinity)) were 0.71 +/- 0.15, 0.67 +/- 0.21, 0.25 +/- 0.10 mu g h/mL (mequindox) and 37.24 +/- 7.98, 36.40 +/- 9.16, 86.39 +/- 16.01 mu g h/mL (M), respectively. The terminal elimination half-lives (t(1/2 lambda z)),) were determined to be 0.15 +/- 0.06, 0.21 +/- 0.09, 0.49 +/- 0.23 h (mequindox) and 5.36 +/- 0.86, 5.39 +/- 0.52, 5.22 +/- 0.35 h (M), respectively. The bioavailabilities (F) of mequindox were 89.4% and 16.6% for i.m. and oral administration. Steady-state distribution volume (V-ss) of 1.20 +/- 0.34 L/kg and total body clearance (Cl-B) of 13.57 +/- 2.16 L/kg h were determined for mequindox after i.v. dosing. After single i.m. and oral administration, peak plasma concentrations (C-max) of 3.04 +/- 1.32, 0.36 +/- 0.13 mu g/mL (mequindox) and 3.81 +/- 0.92, 5.99 +/- 1.16 mu g/mL (M) were observed at t(max) of 0.08 +/- 0.02, 0.32 +/- 0.12 h (mequindox) and 0.66 +/- 0.19, 6.67 +/- 1.03 h (M), respectively. The results showed that mequindox was rapidly absorbed after i.m. or p.o. administration and most of mequindox was transformed to metabolites in chickens, with much higher C(max)s and AUCs of metabolite (M) than those of mequindox in plasma.
- 出版日期2012-8
- 单位华南农业大学; 中国农业科学院上海兽医研究所
