Atmospheric-Pressure Plasma- and TRAIL-Induced Apoptosis in TRAIL-Resistant Colorectal Cancer Cells

作者：Ishaq Musarat^*; Han Zhao Jun; Kumar Shailesh; Evans Margaret D M; Ostrikov Kostya

来源：Plasma Processes and Polymers, 2015, 12(6): 574-582.

DOI：10.1002/ppap.201400207

• apoptosis
• cell cultures
• cold plasmas
• death receptor 5 (DR5)
• plasma treatments

The ideal anti-cancer treatments are those that can selectively kill cancer cells without harming normal cells. Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) is an example of a molecule that can selectively kill cancer cells but not normal cells. However, some tumors are resistant to the TRAIL treatment. We have recently shown that atmospheric cold non-equilibrium gas plasmas (AGPs) selectively induced cell death in melanoma and colorectal cancer cell lines by activating TNF and caspases 3/7 apoptosis pathways. Here, we demonstrated that AGPs can be used to make TRAIL-resistant colorectal cancer cells sensitive to the TRAIL treatment. AGPs plus TRAIL promoted the induction of the death receptor 5 (DR5), thereby enhancing the activation and apoptosis of ROS-dependent caspases 3/7. This study revealed the mechanisms involved in AGP-assisted TRAIL-induced cancer cell death and the associated synergistic effects that AGPs has on TRAIL-resistant colorectal cancer cells.

• 出版日期2015-6
• 单位CSIRO