A Folding Pathway-Dependent Score to Recognize Membrane Proteins

作者：Hadi Alijanvand Hamid^*; Rouhani Maryam; Proctor Elizabeth A; Dokholyan Nikolay V; Moosavi Movahedi Ali A

来源：PLos One, 2011, 6(3): e16778.

DOI：10.1371/journal.pone.0016778

While various approaches exist to study protein localization, it is still a challenge to predict where proteins localize. Here, we consider a mechanistic viewpoint for membrane localization. Taking into account the steps for the folding pathway of alpha-helical membrane proteins and relating biophysical parameters to each of these steps, we create a score capable of predicting the propensity for membrane localization and call it FP(3)mem. This score is driven from the principal component analysis (PCA) of the biophysical parameters related to membrane localization. FP3mem allows us to rationalize the colocalization of a number of channel proteins with the Cav1.2 channel by their fewer propensities for membrane localization.

• 出版日期2011-3-1