Association between serum selenium level and type 2 diabetes mellitus: a non-linear dose-response meta-analysis of observational studies

作者：Wang, Xin-liang; Yang, Tu-bao^*; Wei, Jie^*; Lei, Guang-hua; Zeng, Chao

来源：Nutrition Journal, 2016, 15(1): 48.

DOI：10.1186/s12937-016-0169-6

• Selenium
• Type 2 diabetes mellitus
• Observational studies
• Non-linear dose-response meta-analysis

Background: The association between serum selenium levels and type 2 diabetes mellitus (T2DM) is controversial. We performed a systematic review and non-linear dose-response meta-analysis of observational studies to investigate the association in the present study.
Methods: A comprehensive literature search was conducted using MEDLINE and EMBASE databases. A pooled odds ratio (OR) and related 95 % confidence interval (95 % CI) for T2DM between the highest and lowest serum selenium categories, and a non-linear dose-response relationship between selenium and T2DM were estimated.
Results: A total of five studies (of 13,460 participants) were identified as meeting the inclusion criteria. The pooled OR indicated that there was a significantly higher prevalence of T2DM in the highest category of blood selenium compared with the lowest (OR = 1.63, 95 % CI: 1.04-2.56, P = 0.033). Moreover, a significant non-linear dose-response relationship was observed between serum selenium levels and T2DM (P < 0.001). Serum selenium levels were positively associated with T2DM in populations with relatively low serum selenium levels (<97.5 mu g/l) and those with high serum selenium levels (>132.5 mu g/l).
Conclusions: The positive association between serum selenium levels and T2DM existed in populations with relatively low levels and high levels of serum selenium, indicating a likely U-shaped non-linear dose-response relationship between serum selenium and T2DM.

• 出版日期2016-5-4
• 单位中南大学