科研之友
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摘要
Four novel Cu/TiO2 nanostructured materials have been prepared by the sal gel route in order to be used as a new therapeutic alternative in the treatment of high malignancy tumors. Copper precursors were added to titania during the titanium n-butoxide hydrolysis and final materials were characterized by several physico-chemical techniques. The X-ray diffraction patterns indicate that copper compounds were homogeneously dispersed in the mesoporous structure of amorphous titania. There were no changes observed in the structure of copper compounds co-gelled with titania. The surface area from the N-2 adsorption-desorption isotherms is within the range of 525 m(2)/g and 601 m(2)/g. This article is a report on the evaluation of these copper compounds and their potential anti-proliferative effect in glioma C6 cells in vitro. The results indicate that the survival of glioma cells after 24 hours of incubation with 1000 mu g/ml of Cu/TiO2 material was lower than the control sample and TiO2.
- 出版日期2012-6
