Acute effects of low and high dose alcohol on smoking lapse behavior in a laboratory analogue task

作者：Kahler Christopher W^*; Metrik Jane; Spillane Nichea S; Day Anne; Leventhal Adam M; McKee Sherry A; Tidey Jennifer W; McGeary John E; Knopik Valerie S; Rohsenow Damaris J

来源：Psychopharmacology, 2014, 231(24): 4649-4657.

DOI：10.1007/s00213-014-3613-3

• Alcohol
• Smoking relapse
• Craving
• Urge to smoke
• Stimulation
• Alcohol administration

Smoking lapses (i.e., returns to smoking after quitting) often occur following alcohol consumption with observational data suggesting greater quantities of alcohol lead to greater risk. However, a causal dose-dependent effect of alcohol consumption on smoking lapse behavior has not been established, and the mechanisms that might account for such an effect have not been tested. %26lt;br%26gt;In a within-subjects design, we examined the effects of low- (0.4 g/kg) and high-dose (0.8 g/kg) alcohol, relative to placebo, on smokers%26apos; ability to resist initiating smoking after acute smoking abstinence. %26lt;br%26gt;Participants were 100 heavy alcohol drinkers, smoking 10-30 cigarettes per day. Across three separate days, participants consumed placebo, low-dose, or high-dose alcohol following 3 h of smoking abstinence and, 35 min later, were offered the opportunity to smoke while resisting smoking was monetarily reinforced proportional to the amount of time delayed. %26lt;br%26gt;Consistent with a dose-response effect, participants smoked 3.35 min (95 % confidence intervals (CI) [-7.09, 0.40], p = .08) earlier following low-dose alcohol and 6.36 min (95 % CI [-9.99, -2.73], p = .0006) earlier following high-dose alcohol compared to drinking a placebo beverage. Effects of dose on smoking behavior were partially mediated by increases in urge to smoke. There was no evidence that alcohol%26apos;s effects on urge to smoke or ability to resist smoking were mediated through its stimulating or sedating effects. %26lt;br%26gt;Alcohol can reduce the ability to resist smoking in a dose-dependent fashion, in part, due to its effect on increasing the intensity of smoking urges.

• 出版日期2014-12