MPB64 DNA vaccine with immunogenicity and efficacy against tuberculosis

作者：Yao, Yunyi; Hou, Qian; Jin, Hua; Lin, San; Wang, Yajun; Xue, Jianhong; Sun, Li; Hong, Huarong; Zhou, Xiaoli; Chen, Fang^*

来源：African Journal of Microbiology Research, 2012, 6(7): 1457-1462.

DOI：10.5897/AJMR11.1306

• Tuberculosis
• DNA vaccines
• MPB64
• recombination plasmid
• antibody titer

Tuberculosis is a serious infectious disease caused by Mycobacterium tuberculosis. DNA vaccination is an advanced technique for protecting human bodies from infectious diseases including tuberculosis by injecting exogenous gene engineering DNA into the body to produce an immunological response. In this study, we examined the immunogenicity and protective efficacy of DNA vaccine (pCDNA-MPB64) expressing MPB64 protein and its booster effects in mice for controlling tuberculosis. The results showed that MPB64 DNA vaccine led to a dramatic augmentation of humoral and cellular responses. All these suggested that MPB64 DNA vaccines is an ideal vaccine and may be further developed as a useful method to prevent tuberculosis.

• 出版日期2012-2-23
• 单位吉林大学; 成都医学院; 中国人民解放军总医院; 四川大学; 新疆医科大学