Analysis of Potential Migrants from Plastic Materials in Milk by Liquid Chromatography-Mass Spectrometry with Liquid-Liquid Extraction and Low-Temperature Purification

作者：Bodai Zsolt; Szabo Balint Samuel; Novak Marton; Hamori Susanne; Nyiri Zoltan; Rikker Tamas; Eke Zsuzsanna^*

来源：Journal of Agricultural and Food Chemistry, 2014, 62(41): 10028-10037.

DOI：10.1021/jf503110v

• liquid-liquid extraction with low-temperature purification
• LC-MS/MS
• polymer additives
• migration
• antioxidants
• UV stabilizers
• milk

A simple and fast analytical method was developed for the determination of six UV stabilizers (Cyasorb UV-1164, Tinuvin P, Tinuvin 234, Tinuvin 326, Tinuvin 327, and Tinuvin 1577) and five antioxidants (Irgafos 168, Irganox 1010, Irganox 3114, Irganox 3790, and Irganox 565) in milk. For sample preparation liquidliquid extraction with low-temperature purification combined with centrifugation was used to remove fats, proteins, and sugars. After the cleanup step, the sample was analyzed with high-performance liquid chromatographytandem mass spectrometry (LC-MS/MS). External standard and matrix calibrations were tested. External calibration proved to be acceptable for Tinuvin P, Tinuvin 234, Tinuvin 326, Tinuvin 327, Irganox 3114, and Irganox 3790. The method was successfully validated with matrix calibration for all compounds. Method detection limits were between 0.25 and 10 mu g/kg. Accuracies ranged from 93 to 109%, and intraday precisions were <13%.

• 出版日期2014-10-15