科研之友
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摘要
Sox9, an important member of the Sox gene family, plays a key role in regulating sex determination and cartilage formation in mammals. Sox9 is associated with tumorigenesis in several cancers including breast cancer. Here, we investigated the correlation between the expression of Sox9 and breast cancer stem cells (BCSCs) and the clinicopathological characteristics and prognosis of patients with breast cancer. Sox9 expression was detected by immunohistochemistry and double staining was used to detect the expression of CD44 and CD24 in 420 breast cancer specimens. We used statistical methods to evaluate the relationship between Sox9 and clinicopathological features and the impact of BCSCs on overall survival (OS) and disease-free survival (DFS). Our results showed that Sox9 expression was closely associated with estrogen receptor and progesterone receptor levels, Ki-67, p53, lymph node metastasis (LNM), and BCSCs. High expression levels of Sox9 and positive BCSCs status were correlated with poor OS and DFS, and patients with both Sox9 upregulation and BCSCs had the worst prognosis. Multivariate analysis showed that Sox9 expression, LNM, and BCSCs were independent prognostic factors for OS and DFS. Taken together, our results suggest that high Sox9 expression levels are correlated with positive BCSCs status and both are predictors of poor OS and DFS in patients with breast cancer. Sox9 may be used as a biomarker and a therapeutic target for eliminating BCSCs.
- 出版日期2016
- 单位哈尔滨医科大学
