Acute leukoencephalopathy after buprenorphine intoxication in a 2-year-old child

作者：Bellot Blandine; Michel Fabrice^*; Thomachot Laurent; Chaumoitre Kathia; Battaglia Fabrice; Lagier Pierre

来源：European Journal of Paediatric Neurology, 2011, 15(4): 368-371.

DOI：10.1016/j.ejpn.2011.03.002

• Buprenorphine
• Intoxication
• Pediatrics
• Leukoencephalopathy

Leukoencephalopathies have been reported after heroin inhalation or ingestion, and buprenorphine injection, but the physiopathology remains unclear. We report here the first case of leukoencephalopathy caused by buprenorphine ingestion in a 2-year-old child who was admitted for coma and fever. Due to technical problems, the toxicology screen was delayed, and infectious disease was first suspected. A brain MRI found bilateral and symmetric white matter damages in the cerebral hemispheres and the cerebellum. Rapid recovery and positive toxicology screen for buprenorphine on day 4 confirmed the diagnosis of acute intoxication.

• 出版日期2011-7