Modeling antibiotic resistance in hospitals: The impact of minimizing treatment duration

作者：D'; Agata Erika M C; Magal Pierre; Olivier Damien; Ruan Shigui; Webb Glenn F

来源：Journal of Theoretical Biology, 2007, 249(3): 487-499.

DOI：10.1016/j.jtbi.2007.08.011

• antibiotic-resistant bacteria
• individual-based model
• differential equation model
• basic reproduction number

Infections caused by antibiotic-resistant pathogens are a global public health problem. Numerous individual- and population-level factors contribute to the emergence and spread of these pathogens. An individual-based model (IBM), formulated as a system of stochastically determined events, was developed to describe the complexities of the transmission dynamics of antibiotic-resistant bacteria. To simplify the interpretation and application of the model';s conclusions, a corresponding deterministic model was created, which describes the average behavior of the IBM over a large number of simulations. The integration of these two model systems provides a quantitative analysis of the emergence and spread of antibiotic-resistant bacteria, and demonstrates that early initiation of treatment and minimization of its duration mitigates antibiotic resistance epidemics in hospitals.

• 出版日期2007-12-7