The relationship between vascular endothelial dysfunction and treatment frequency in neovascular age-related macular degeneration

作者：Ueda Consolvo Tomoko^*; Hayashi Atsushi; Ozaki Mayumi; Nakamura Tomoko; Yagou Takaaki; Abe Shinya

来源：Japanese Journal of Ophthalmology, 2017, 61(4): 347-353.

DOI：10.1007/s10384-017-0515-z

• Neovascular age-related macular degeneration
• Endothelial dysfunction
• Antivascular endothelial growth factor
• Peripheral arterial tonometry
• Reactive hyperemia index

To assess the correlation between endothelial dysfunction and frequency of antivascular endothelial growth factor (anti-VEGF) treatment for neovascular age-related macular degeneration (nAMD).
We examined 64 consecutive patients with nAMD who were evaluated for endothelial function by use of peripheral arterial tonometry (EndoPAT 2000; Itamar Medical, Caesarea, Israel) at Toyama University Hospital from January 2015. We tallied the number of anti-VEGF treatments between January 2014 and December 2015 and determined the correlation between the number of anti-VEGF injections and endothelial function expressed as the reactive hyperemia index (RHI). Multiple regression analysis was also performed to identify the independent predictors of a larger number of injections.
The mean number of anti-VEGF injections was 8.2 +/- 3.3. The mean lnRHI was 0.47 +/- 0.17. The lnRHI correlated with the number of anti-VEGF injections (r = -0.56; P = 0.030). The multiple regression analysis revealed that endothelial function, neovascular subtypes, and treatment regimens were associated with the number of injections.
Endothelial dysfunction may affect the efficacy of anti-VEGF therapy. Neovascular subtypes may also predict a larger number of injections.

• 出版日期2017-7