Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response

作者：Gomes Larissa Rodrigues; Rivas Totino Paulo Renato; Arroyo Sanchez Maria Carmen; da Silva Kaingona Daniel Elsa Paula; de Macedo Cristiana Santos; Fortes Filomeno; Coura Jose Rodrigues; Di Santi Silvia Maria; Werneck Guilherme Loureiro; Suarez Mutis Martha Cecilia; Ferreira da Cruz Maria de Fatima; Daniel Ribeiro Claudio Tadeu^*

来源：Memorias do Instituto Oswaldo Cruz, 2013, 108(6): 796-800.

DOI：10.1590/0074-0276108062013018

• Plasmodium falciparum
• Plasmodium vivax
• glycosylphosphatidylinositol
• asymptomatic infection
• Brazilian Amazon
• Angola

Anti-glycosylphosphatidylinositol (GPI) antibodies (Abs) may reflect and mediate, at least partially, anti-disease immunity in malaria by neutralising the toxic effect of parasitic GPI. Thus, we assessed the anti-GPI Ab response in asymptomatic individuals living in an area of the Brazilian Amazon that has a high level of malaria transmission. For comparative purposes, we also investigated the Ab response to a crude extract prepared from Plasmodium falciparum, the merozoite surface protein (MSP)3 antigen of P. falciparum and the MSP 1 antigen of Plasmodium vivax (PvMSP1-(19)) in these individuals and in Angolan patients with acute malaria. Our data suggest that the Ab response against P. falciparum GPI is not associated with P. falciparum asymptomatic infection in individuals who have been chronically exposed to malaria in the Brazilian Amazon. However, this Ab response could be related to ongoing parasitaemia (as was previously shown) in the Angolan patients. In addition, our data show that PvMSP1-(19) may be a good marker antigen to reflect previous exposure to Plasmodium in areas that have a high transmission rate of P. vivax.

• 出版日期2013-9
• 单位河北医科大学