A concise approach for the synthesis of 3-iodoindoles and 3-iodobenzo[b]furans via Ph3P-catalyzed iodocyclization

作者：Li Yin Long; Li Jian; Yu Sheng Nan; Wang Ji Bo; Yu Yan Min; Deng Jun^*

来源：Tetrahedron, 2015, 71(43): 8271-8277.

DOI：10.1016/j.tet.2015.09.005

• 3-Iodoindoles
• 3-Iodobenzo[b]furans
• Triphenylphosphine
• Iodocyclization
• N-iodosuccinimide

A variety of 3-iodoindole and 3-iodobenzo[b]furan derivatives were conveniently prepared from the corresponding 2-alkynylanilines and 2-alkynylphenols through Ph3P-catalyzed iodocyclization in the presence of N-iodosuccinimide (NIS). This protocol provides a rapid access to 3-iodoindoles and 3-iodobenzo[b]furans in good to excellent yields under mild conditions.

• 出版日期2015-10-28
• 单位天津大学