The Relationship of Serum Erythropoietin Level With Coronary Collateral Grade

作者：Sahinarslan Asife^*; Yalcin Ridvan; Kocaman Sinan Altan; Ercin Ugur; T****p Ali Cevat; Topal Salih; Bukan Neslihan; Boyaci Bulent; Cengel Atiye

来源：Canadian Journal of Cardiology, 2011, 27(5): 589-595.

DOI：10.1016/j.cjca.2011.04.001

Background: Erythropoietin has been shown to induce neovascularization and protect against ischemic vascular injury. We investigated whether a higher serum erythropoietin (EPO) level is related to better coronary collateral vessel grade.
Methods: Ninety-nine patients with stable angina pectoris who have at least 1 coronary stenosis of equal to or greater than 70% at coronary angiography were prospectively enrolled. Serum EPO and vascular endothelial growth factor (VEGF) levels were studied. Coronary collateral degree was graded according to the Rentrop method. Patients with grade 2-3 collateral degree were included in the good collateral group and formed Group I. The patients with grade 0-1 collateral degree were included in the poor collateral group and formed Group II.
Results: The serum EPO level was significantly higher in the good collateral group (17.3 +/- 9.3 mU/mL vs 11.7 +/- 5.0 mU/mL; P < 0.001). There was also a positive correlation between serum EPO level and Rentrop score (r = 0.39; P < 0.001). In multivariate analysis, serum EPO level (odds ratio [OR] 1.336; 95% confidence interval [CI], 1.120-1.593; P = 0.001), oxygen saturation (OR 0.638; 95% CI, 0.422-0.963; P = 0.033) and presence of chronic total occlusion (CTO) (OR 26.7; 95% CI, 3.874-184.6; P = 0.001) were independently related to well-developed coronary collaterals.
Conclusions: Higher serum EPO level is related to better coronary collateral development. Erythropoietin may have a positive effect on the development of collaterals and may provide a new agent for the treatment strategies to enhance coronary collateral vessel development.

• 出版日期2011-10