Sex differences in risk factors of uncomplicated colonic diverticulosis in a metropolitan area from Northern China

作者：Yang, Fang; Zheng, Yanmin; Jiang, Xihui; Su, Zhengyan; Wang, Ya; Lin, Lin; Lv, Houning; Zhang, Jie; Zhao, Jingwen; Wang, Bangmao; Jiang, Kui^*; Sun, Chao^*

来源：Scientific Reports, 2018, 8(1): 138.

DOI：10.1038/s41598-017-18517-1

• RHEUMATOID-ARTHRITIS
• GUT MICROBIOTA
• PREVALENCE
• DISEASE
• DIET
• OUTCOMES
• OBESITY

As the world's most populated and rapidly aging country, there is limited information on sex-related differences in factors regarding uncomplicated colonic diverticulosis in China. We aimed to investigate sex differences in individual risk factor in a northern metropolis. Patients with colonic diverticulosis who underwent indicated colonoscopy were queried with respect to medical history and demographic features. Demographic information, life style factors and co-morbidities were retrieved from a prospective dataset. Multiple regression analyses were performed to determine precipitating factors of diverticula. Of 4,386 enrolled patients, colonic diverticulosis were detected in 218 cases (4.97%). Multiple logistic regression analysis implicated increasing age (OR = 1.05, 95% CI 1.03-1.06, P < 0.001), red meat >= 100 g/d (OR = 2.53, 95% CI 1.72-3.70, P < 0.001), smoking (OR = 2.14, 95% CI 1.05-4.33, P = 0.035), rheumatologic diseases (OR = 3.38, 95% CI 1.09-10.5, P = 0.035) and NSAIDs (OR = 2.11, 95% CI 1.12-3.97, P = 0.020) were significantly associated with diverticulosis in men, whilst advancing age (OR = 1.03, 95% CI 1.01-1.05, P = 0.013), BMI (OR = 1.12, 95% CI 1.04-1.19, P = 0.001), smoking (OR = 10.2, 95% CI 2.81-37.4, P < 0.001), rheumatologic diseases (OR = 8.04, 95% CI 3.05-21.2, P < 0.001), hypertension (OR = 1.76, 95% CI 1.01-3.06, P = 0.047), colonic polyps (OR = 3.12, 95% CI 1.82-5.36, P < 0.001) and antihypertensive medications (OR = 2.99, 95% CI 1.66-5.39, P < 0.001) in women. In conclusion, it is pivotal to take account of differentially sex-related factors in regard to the development of uncomplicated colonic diverticulosis.

• 出版日期2018-1-9
• 单位天津医科大学