Dose-response and time-response analysis of total fatty acid ethyl esters in meconium as a biomarker of prenatal alcohol exposure

作者：Kwak Ho Seok; Han Jung Yeol^*; Choi June Seek; Ahn Hyun Kyong; Kwak Dong Wook; Lee Yeon Kyung; Koh Sun Young; Jeong Go Un; Velazquez Armenta E Yadira; Nava Ocampo Alejandro A

来源：Prenatal Diagnosis, 2014, 34(9): 831-838.

DOI：10.1002/pd.4374

ObjectivesLittle is known on how the dose and timing of exposure co-influence the cumulative concentration of fatty acid ethyl esters (FAEEs) in meconium. The objective of the study was to assess the cumulative concentration of FAEEs in meconium as a biomarker of light, moderate, or heavy prenatal alcohol exposure occurring at either first, second, or third trimesters of pregnancy.
MethodsHistory of prenatal alcohol exposure was obtained in the 34th week of gestation from 294 pregnant women. Meconium was collected from their babies within the first 6 to 12h after birth and examined for the presence of nine FAEEs.
ResultsNo significant differences were identified between the cumulative levels of FAEEs in the meconium from the babies born to abstainers and those born to mothers with history of light-to-moderate prenatal alcohol exposure during their pregnancy.
ConclusionsLight-to-moderate prenatal alcohol exposure cannot be reliably predicted by the cumulative FAEE concentrations in meconium of exposed babies. A cumulative FAEE level of >10nmol/g would be required to consider that prenatal alcohol exposure during the second to third trimesters occurred at risky levels in the absence of reliable maternal history of ethanol exposure.

• 出版日期2014-9