Aversive Prediction Error Signals in the Amygdala

作者：McHugh Stephen B^*; Barkus Christopher; Huber Anna; Capitao Liliana; Lima Joao; Lowry John P; Bannerman David M

来源：Journal of Neuroscience, 2014, 34(27): 9024-9033.

DOI：10.1523/JNEUROSCI.4465-13.2014

• amygdala
• fear
• hemodynamic
• prediction error
• theta oscillations
• tissue oxygen

Prediction error signals are fundamental to learning. Here, in mice, we show that aversive prediction signals are found in the hemodynamic responses and theta oscillations recorded from the basolateral amygdala. During fear conditioning, amygdala responses evoked by footshock progressively decreased, whereas responses evoked by the auditory cue that predicted footshock concomitantly increased. Unexpected footshock evoked larger amygdala responses than expected footshock. The magnitude of the amygdala response to the footshock predicted behavioral responses the following day. The omission of expected footshock led to a decrease below baseline in the amygdala response suggesting a negative aversive prediction error signal. Thus, in mice, amygdala activity conforms to temporal difference models of aversive learning.

• 出版日期2014-7-2