Associations between blood metals and fecundity among women residing in New York State

作者：Bloom Michael S^*; Louis Germaine M Buck; Sundaram Rajeshwari; Kostyniak Paul J; Jain Jinesh

来源：Reproductive Toxicology, 2011, 31(2): 158-163.

DOI：10.1016/j.reprotox.2010.09.013

• Arsenic (As)
• Cadmium (Cd)
• Fecundity
• Lead (Pb)
• Magnesium (Mg)
• Nickel (Ni)
• Selenium (Se)
• Zinc (Zn)

Trace exposures to metals may affect female reproductive health. To assess the relation between trace concentrations of blood metals and female fecundity, 99 non-pregnant women discontinuing contraception for the purpose of becoming pregnant were prospectively followed. Participants completed a baseline interview and daily diaries until pregnant, or up to 12 menstrual cycles at risk for pregnancy; home pregnancy test kits were used. For 80 women, whole blood specimens were analyzed for arsenic, cadmium, lead, magnesium, nickel, selenium and zinc using inductively coupled plasma mass spectrometry (ICP-MS). Time to pregnancy was estimated using Cox proportional hazards models for discrete time. Metal concentrations were generally within population reference intervals. Adjusted models suggest a 51.5% increase in the probability for pregnancy per 3.60 mu g/L increase in Mg (P=0.062), and a 27.7% decrease per 0.54 mu g/L increase in Zn (P=0.114). Findings indicate that Mg and Zn may impact female fecundity, but in varying directions.

• 出版日期2011-2