An Extremely Facile Synthesis of Furans, Pyrroles, and Thiophenes by the Dehydrative Cyclization of Propargyl Alcohols

作者:Aponick Aaron*; Li Chuan Ying; Malinge Jeremy; Marques Emerson Finco
来源:Organic Letters, 2009, 11(20): 4624-4627.
DOI:10.1021/ol901901m

摘要

Furans, pyrroles, and thiophenes are efficiently prepared by gold-catalyzed dehydrative cyclizations of readily available, heteroatom-substituted propargylic alcohols. The reactions are rapid, high-yielding, and procedurally simple, giving essentially pure aromatic heterocycles in minutes under open-flask conditions with catalyst loadings as low as 0.05 mol %.

  • 出版日期2009-10-15