A multi-scaled hybrid orthopedic implant: bone ECM-shaped Sr-HA nanofibers on the microporous walls of a macroporous titanium scaffold

作者：Han, Yong^*; Zhou, Jianhong; Zhang, Lan; Xu, Kewei

来源：Nanotechnology, 2011, 22(27): 275603.

DOI：10.1088/0957-4484/22/27/275603

• PEPTIDE-AMPHIPHILE NANOFIBERS
• HYDROTHERMAL TREATMENT
• LIQUID-CHROMATOGRAPHY
• POROUS TITANIUM
• OXIDE FILMS
• IN-VIVO
• HYDROXYAPATITE
• OXIDATION
• SURFACES
• GROWTH

We report here, for the first time, a novel multi-scaled hybrid orthopedic implant material consisting of a macroporous Ti scaffold, whose macropores' walls have a microporous titania layer which is fully covered with nanofibers of Sr-doped hydroxyapatite (Sr-HA). The microporous titania layer is formed on and within the Ti scaffold by micro-arc oxidation, which firmly binds to the Ti substrate and contains Ca(2+,) Sr(2+) and PO(4)(3-) ions. It is then hydrothermally treated to form Sr-HA nanofibers. During the hydrothermal treatment, Sr-HA nanoprisms nucleate from Ca(0.5)Sr(0.5)TiO(3) pre-formed on the TiO(2) and grow in length to nanofibers at the expense of Ca(2+), Sr(2+) and PO(4)(3-) ions that migrate from the TiO(2). These Sr-HA nanofibers construct a network structure similar to the hierarchical organization of bone extracellular matrix (ECM), and the resulting nanofibrous surface displays a firm adhesion to substrate, superhydrophilicity and apatite-inducing ability. The induced apatite prefers to nucleate on the basal-faceted surfaces of Sr-HA nanofibers. The nanofiber-walled scaffold has a great potential for load-bearing orthotopic use.

• 出版日期2011-7-8
• 单位西安交通大学