Dynamic changes in Th1, Th17, and FoxP3+T cells in patients with acute cellular rejection after cardiac transplantation

作者：Wang, Sihua; Li, Jun; Xie, Aini; Wang, Guohua; Xia, Ni; Ye, Ping; Rui, Lu; Xia, Jiahong^*

来源：Clinical Transplantation, 2011, 25(2): E177-E186.

DOI：10.1111/j.1399-0012.2010.01362.x

• acute cellular rejection
• cardiac transplantation
• cytokine
• Th1
• Th17

Previously, studies suggest that CD4+ effector T-cell subsets participate in allograft rejection. However, the dynamic changes and relative roles of these CD4+ effector T-cell subsets, especially Th17 cells, have not been systemically examined in patients with acute rejection after cardiac transplantation. In this study, we have studied and compared these CD4+ T-cell subsets in peripheral blood and endomyocardial biopsies (EMB) in patients with stable-graft and acute cellular rejection. We observed that the gene expressions including T-bet, IFN-gamma, ROR gamma t, IL-17, IL-23, and FoxP3, the functional marker of Th1, Th17, and FoxP3+ CD4+ T cells, were elevated in EMB samples from patients with acute graft rejection. Accordingly, the percentages of circulating Th1, Th17, and FoxP3+ CD4+ T cells were also significantly increased. The data suggest that Th1, Th17, and FoxP3+ CD4+ T cells are associated with acute graft rejection in patients with cardiac transplantation.

• 出版日期2011-3
• 单位华中科技大学; 中国医学科学院阜外医院